Vancomycin mechanism of action

Vancomycin Mechanism of Action Resistance and More

Vancomycin: Mechanism of Action, Drug Interactions & Side

Mechanism of Action . Vancomycin does not bind to Penicillin-Binding Proteins (PBPs) but does bind to precursors of cell wall synthesis. The binding interferes with the ability of the PBP enzymes, such as transpeptidases and tranglycosylases, to incorporate the precursors into the growing cell wall. Biosynthesis of Staphylococcal peptidoglyca The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix, which forms the major structural component of Gram-positive cell walls Mechanism of Action: Vancomycin inhibits transpeptidation by binding to D-alanyl-D-alanine residues of the bacterial cell wall

Vancomycin is an antibiotic. Oral (taken by mouth) vancomycin fights bacteria in the intestines. Vancomycin is used to treat an infection of the intestines caused by Clostridium difficile, which can cause watery or bloody diarrhea. This medicine is also used to treat staph infections that can cause inflammation of the colon and small intestines Vancomycin is a tricyclic glycopeptide that has gained clinical importance thanks to its effectiveness against organisms such as MRSA and enterococci. It has. Home; Animations; Psychopharmacology; PowerPoints; About; Vancomycin mechanism of action: an animation. Author: Flavio Guzman, MD Lesson on the antibiotic Vancomycin, what bacteria vancomycin targets, the mechanism of action of vancomycin, and adverse effects of vancomycin. Vancomycin i.. VANCOMYCIN Mechanism of ActionVancomycin is an antibiotic drug which is structurally classified as a glycopeptide. It mainly acts by prevention of cell-wall.

Vancomycin DrugBank Onlin

The mechanism of vancomycin action on peptidoglycan synthesis is clearly different from that of moenomycin and bacitracin. In the presence of these antibiotics, peptidoglycan synthesis is inhibited with both UDP-MurNAc-pentapeptide and -tetrapeptide as substrates. In addition, these results provide additional insight into the mechanism of. Glycopeptide antibiotics, including vancomycin and teicoplanin, are large, rigid molecules that inhibit a late stage in bacterial cell wall peptidoglycan synthesis. The three-dimensional structure contains a cleft into which peptides of highly specific configuration (L-aa-D-aa-D-aa) can fit: such sequences are found only in bacterial cell walls, hence glycopeptides are selectively toxic

The two combined vancomycin modifications and the accompanying two synergistic mechanisms of action provide a vancomycin analog >1,000-fold more active than vancomycin against the most stringent vancomycin-resistant organisms, VanA VRE, displaying superb in vitro MICs (0.16 μg/mL) Mechanism of action. The bactericidal action of vancomycin results primarily from inhibition of cell wall biosynthesis. In addition, vancomycin alters bacterial cell membrane permeability and RNA synthesis. There is no cross resistance between vancomycin and other antibiotics. Microbiology Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021. Instead, the best characterized effect of daptomycin is the permeabilization and depolarization of the bacterial cell membrane. This activity, which can account for daptomycin's bactericidal effect, correlates with the level of phosphatidylglycerol (PG) in the membrane

Vancomycin Pharmacology Indications, Mechanism, and Side

Mechanism Of Resistance To Vancomycin Because vancomycin does not interact with cell wall biosynthetic enzymes but forms complexes with peptidoglycan precursors, its activity is not determined by the affinity for a target enzyme but by the substrate specificity of the enzymes that determine the structure of peptidoglycan precursors Vancocin - Clinical Pharmacology Mechanism of Action. Vancomycin is an antibacterial drug [see Microbiology ( 12.4 )]. Pharmacokinetics. Vancomycin is poorly absorbed after oral administration. During multiple dosing of 250 mg every 8... Microbiology. The bactericidal action of vancomycin against. Mechanism of Action. Vancomycin binds to the peptide component of peptidoglycan and physically prevents its cross-linking with the glycan component (See: bacterial cell wall ). Thus, vancomycin ultimately disrupts peptidoglycan synthesis, similar to beta-lactam antibiotics Which of the following describes the mechanism of action of vancomycin? Vancomycin prevents cell wall formation in gram positive bacteria. Vancomycin prevents DNA synthesis in gram positive.. Vancomycin inhibits the synthesis of peptidoglycan in membrane preparations from Gaffkya homari with uridine diphosphate-N-acetylmuramyl (UDP-Mur-NAc)-pentapeptide as substrate, but not with either UDP-MurNAc-tetrapeptide or UDP-MurNAc-tripeptide. These results are correlated with the specificity studies described by Perkins and Nieto for complex formation between the antibiotic and the peptide subunit

Vancomycin - Wikipedi

  1. The biochemical mechanism of action of vancomycin is based on the high affinity of this antibiotic for the d -alanyl- d -alanine (D-ala-D-ala) residue, a ubiquitous component of the bacterial cell wall precursor Lipid II
  2. ; infuse slowly -> otherwise 'red man syndrome'.
  3. The primary mechanism of action of vancomycin involves sequestration of this substrate (d -Ala- d -Ala) for a late-stage enzyme-catalyzed (transpeptidase) reaction used for cell wall cross-linking (13)
  4. Posts Tagged vancomycin mechanism of action. أدوية. فانكومايسين vancomycin مضاد حيوي قوي ومضاد للجراثيم.
  5. ate synthesis by binding the D ala D ala oligopeptides. T/F vancomycin is bacterocidal. T. what is the one bug for which vancomycin is added with ceftriaxone in the empiric treatment of meningitis
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Therapeutic Effects: Bactericidal action against susceptible organisms. Spectrum: Active against gram-positive pathogens, including Staphylococci (including methicillin-resistant strains of Staphylococcus aureus), Group A beta-hemolytic streptococci, Streptococcus pneumoniae, Corynebacterium, Clostridium difficile, Enterococcus faecalis. Vancomycin 1. Presented by Helena H. Quezon Clinical Approach to Advanced Pharmacology MSNE 5356 2. Vancomycin Vanquish Vancomycin was first discovered in 1950 and was approved by the Federal Drug and Agency (FDA) in 1958. It became an option to treat an increasing Penicillin resistant Staphylococcus infection in the 50's. The emergence of Methicillin resistant Staphylococcus aureus (MRSA Figure 2 - Vancomycin mechanism of action Examples and coverage Vancomycin - used orally for severe C. difficile infections, or intravenously for severe soft tissue/bone/joint infections as gram-positive cover

Vancomycin - Mechanism, Indication, Contraindications

Mechanism of Action DIFICID is bactericidal therapy that targets Clostridioides difficile. DIFICID has been shown to be active against most isolates of C. difficile, both in vitro and in clinical infections Vancomycin injection is used to treat infections in many different parts of the body. It is also used in patients with heart valve disease (eg, rheumatic fever) or prosthetic (artificial) heart valves who are allergic to penicillin View Hospira Vancomycin HCl mechanism of action for pharmacodynamics and pharmacokinetics details. MIMS Class . Other Antibiotics. ATC Classification . J01XA01 - vancomycin ; Belongs to the class of glycopeptide antibacterials. Used in the systemic treatment of infections. Regulatory Classification.

Antibiotics in dentistry

Glycopeptides (Vancomycin, Teicoplanin): Mechanism of

action, the biaryl group is responsible for cell membrane depolarization. The superior activity against gram-positive pathogens, including those resistant to vancomycin, is be- cause of this dual mechanism of action: either inhibition of cell wall biosynthesis or disruption of membrane integrity (1 Thus, the mechanism of action of daptomycin may involve multiple activities. Included among these would be effects on membrane integrity, rapid inhibition of protein, DNA, and RNA synthesis, and inhibition of lipoteichoic acid synthesis. Unlike cell-wall active agents, daptomycin causes rapid bactericidal activity without cell lysis Vancomycin injection is an antibiotic used to treat serious bacterial infections. Common side effects of vancomycin injection include pain, redness, and tenderness at the injection site. Serious side effects of vancomycin injection include ringing in the ears, hearing problems, change in the amount of urine, easy bleeding/bruising, fever, persistent sore throat, persistent diarrhea ConspectusSince its discovery, vancomycin has been used in the clinic for >60 years. Because of their durability, vancomycin and related glycopeptides serve as the antibiotics of last resort for the treatment of protracted bacterial infections of resistant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant (MDR) Streptococcus.

Vancomycin C66H75Cl2N9O24 - PubChe

Vancomycin review; About vancomycin; Learn vancomycin faster with picmonic (nclex nursing school) Vancomycin-resistant enterococci (vre) in healthcare environ... Vancomycin/ bacterial targets, mechanism of action, adverse Vancomycin: what you need to know; Vancomycin Revie 3.2. Proteomic Adaptation to Vancomycin. The proposed mechanism of action for vancomycin includes the binding of the antimicrobial molecule to an essential precursor in cell wall synthesis, which results in a slow killing rate of this antibiotic and causes a bacteriostatic effect in C. difficile Vancomycin Mechanism of Action. Vancomycin Coverage. Vancomycin Side Effects. Vancomycin Absorption. Vancomycin Metabolism. Vancomycin Distribution. Vancomycin Elimination. Vancomycin Therapeutic Goals. Vancomycin Background. Equations Explained 8 Topics | 1 Puzzle Expand Vancomycin pharmacokinetics have been described in numerous studies for 25 years. This review presents a synthesis of the reported population pharmacokinetic models of vancomycin. The objective was to determine if there was a consensus on a structural model and which covariates were identified

Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. It is a naturally occurring compound found in the soil saprotroph Streptomyces roseosporus.Its distinct mechanism of action makes it useful in treating infections caused by multiple drug-resistant bacteria Gentamicin is a broad spectrum antibiotic and it is bacteriocidal in action. The aminoglycosides are bactericidal in action unlike the tetracyclines which are bacteriostatic in action. The binding of the aminoglycosides to the 30S ribosomal subunit of the bacterial ribosome during protein synthesis is irreversible; and this is why antibiotics in this category are bacteriocidal in action

Vancomycin Uses, Dosage, Side Effects - Drugs

  1. ation of normal gut flora by commonly used broad-spectrum antibiotics (vancomycin, cephalosporins, and metronidazole) encourages the selective proliferation of VRE . This increases the likelihood of.
  2. al pain.When vancomycin is taken by mouth, it stays in the intestines to stop the growth of bacteria that cause these symptoms.. This antibiotic treats only bacterial infection in the intestines
  3. istration. During multiple dosing of 250 mg every 8 hours for 7 doses, fecal concentrations of vancomycin in volunteers exceeded 100 mg/kg in the majority of.
  4. oglycoside to the bacterial ribosome 30S subunit. Pharmacodynamics: A
  5. Vancomycin is an antibiotic. Oral (taken by mouth) vancomycin fights bacteria in the intestines. Vancomycin is used to treat an infection of the intestines caused by Clostridium difficile, which.
  6. Structure, biochemistry and mechanism of action of glycopeptide antibiotics. Eur J Clin Microbiol Infect Dis 1989; 8:943. Fines M, Perichon B, Reynolds P, et al. VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405
  7. Vancomycin has only rarely been implicated as a cause of thrombocytopenia, and there is only limited evidence that this complication is caused by immune mechanisms. We conducted a study to.

Vancomycin mechanism of action: an animation CME at

  1. Considerable literature is presented in support of the thesis. Drug toxicity is rationalized based on the fundamental approach to vancomycin action. This review represents another example in support of the prior ET-ROS-OS unifying mechanism for anti-infective and toxic action. Novel insight may aid in improved drug design
  2. Following incubation and UV-cross-linking, the samples were separated by TLC, and the plates were dried and autoradiographed. - Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteri
  3. Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteria Alexey Ruzin,* Guy Singh, Anatoly Severin, Youjun.
  4. Mechanism of Action. Inhibits cell-wall biosynthesis; blocks glycopeptide polymerization by binding tightly to D-alanyl-D-alanine portion of cell wall precursor. Absorption Oral. Poorly absorbed; After 250-mg capsules PO q8hr for 7 doses, fecal concentrations of vancomycin in volunteers exceeded 100 mcg/g in majority of samples; I
  5. e (NAG) peptides from linking together for
  6. -Mechanism of action-Binds to TPCs-Prevents binding of tetrapeptidase-No attachment of PG layers -> no cell wall-Associated with kidney toxicity-Vancomycin can only be used to treat G+ infections because of its very large size, it is a very large antibiotic that will not fit through G-porins of outer membrane-G+ bacteria becomes resistant to.
  7. 1 VANCOMYCIN. Vancomycin is a glycopeptide antimicrobial with antibacterial action, acting by inhibition of cell wall synthesis. It was introduced in clinical practice in the mid‐1950s for the treatment of bacterial infections caused by Gram‐positive bacteria and it is considered by the Infectious Disease Society of America (IDSA) as the first treatment option for methicillin‐resistant.

Interestingly, this resistance mechanism seems not to have evolved in pathogen bacteria itself, but has been borrowed from bacteria which produce Vancomycin and need this as a self-defense (for more, see reference 2). Vancomycin forms a pocket around the d-Ala-d-Ala substrate, which is impaired in the resistant form A series of vancomycin C-terminus guanidine modifications is disclosed that improves antimicrobial activity, enhances the durability of antimicrobial action against selection or induction of resistance, and introduces a synergistic mechanism of action independent of d-Ala-d-Ala binding and inhibition of cell wall biosynthesis. The added mechanism of action results in induced bacterial cell. Mechanism of Action of Vancomycin - Animation | Animations | PharmaXChange.info Vancomycin is an antibiotic drug which is structurally classified as a glycopeptide. It mainly acts by prevention of cell-wall biosynthesis of bacteria دواء Vancomycin 1000mg Vial About Vancomycin A tricyclic glycopeptide antibiotic. Mechanism of Action of Vancomycin Vancomycin binds to the terminal dipeptide sequence of peptidoglycan and inhibits the association and cross linking of peptidoglycan and as the result inhibit cell wall synthesis Indications for Vancomycin 1. Endocarditis 2

Vancomycin Bacterial Targets, Mechanism of Action

In support of apoptotic mechanism, overactivation of poly (adenosine diphosphate ribose) polymerase 1 (PARP-1) activity, a pathway involved in DNA repair, has been demonstrated in rats administered vancomycin [Dalaklioglu et al. 2010]. In this study, concurrent treatment with 1,5-isoquinelinediol, a PARP inhibitor, attenuated the intensity of. Vancomycin is a glycopeptide antibiotic used in the treatment of Gram-positive infections, particularly methicillin-resistant Staphylococcus aureus (MRSA). Mechanism of action Inhibits cell wall formation by binding to D-Ala-D-Ala moieties, preventing polymerization of peptidoglycan Mechanism of action. Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units. The drug is bactericidal for dividing microorganisms Vancomycin is a cyclic peptide with antibiotic action, obtained by fermentation of the bacterium Amicolatopsis orientalis . It has a spectrum of action restricted to Gram-positive bacteria and is particularly useful against multi-resistant ones. Vancomycin is marketed in pharmaceutical formulations suitable for oral administration and intravenous infusio

Mechanism of action. Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria. The mechanism inhibited, and various factors related to entering the outer membrane of Gram-negative organisms mean that vancomycin is not active against Gram-negative bacteria.. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG. Mechanism of Action (Mandell et al. Principles & Practice of Infectious Diseases, 6th ed., 2005) - Glycopeptide • Binds to peptidoglycan precursor - D-alanyl-D-alanine terminating pentapeptide - Serum vancomycin concentration 80 to 100 µg/mL - serum vancomycin concentrations in all. Mechanism of action . Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units. The drug is slowly bactericidal for dividing microorganisms Mechanism of Action: Inhibits bacterial cell wall synthesis by blocking glycopeptide polymerization through binding tightly to D-alanyl-D-alanine portion of cell wall precursor. Dosing interval in renal impairment (vancomycin levels should be monitored in patients with any renal impairment) The mechanism of action is the biochemical way in which a drug is pharmacologically effective. This can be a specific target where the drug binds like an enzyme, as is the case with many antibiotics, or a receptor. Mechanism of action describes the biochemical process specifically at a molecular level

VANCOMYCIN Mechanism of Action - YouTub

Vancomycin is a bactericidal antibiotic (it kills bacteria) that exerts its effects by preventing bacteria from forming cell walls, which they need to survive. Vancomycin is only effective against gram-positive bacteria. Oral vancomycin is poorly absorbed, and ingestion does not result in significant levels of drug in the body Vancomycin also inhibits transglycosylase (glycosyltransferase), a second enzyme responsible for cross-linking sugar residues, although this appears to be a less important mechanism compared to inhibition of transpeptidase.The mechanism for transglycosylase inhibition is unclear Mechanism of Action. The bactericidal action of vancomycin against Staphylococcus aureus and the vegetative cells of Clostridioides difficile results primarily from inhibition of cell-wall biosynthesis. In addition, vancomycin alters bacterial-cell-membrane permeability and RNA synthesis Mechanisms of Vancomycin Resistance The true mechanism of vancomycin resistance in these species, though currently unknown, is a topic of active investigation. Vancomycin acts by binding irreversibly to the terminal d -alanyl- d -alanine of cell wall disaccharide-pentapeptide precursors, thereby inhibiting production of the bacterial cell wall Vancomycin is used to a treat a bacterial infection in your bowel caused by Clostridium difficile (C. difficile).Infection with C. difficile most commonly occurs in people who have recently had a course of antibiotics and are in hospital

Vancomycin Hydrochloride is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci.At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall. The glycopeptide antibiotic vancomycin has bactericidal activity against aerobic and anaerobic Gram-positive bacteria including multi-resistant staphylococci. However, there are reports of Staphylococcus aureus with reduced susceptibility to glycopeptides. There are increasing reports of glycopeptide-resistant enterococci Five Basic Mechanisms of Antibiotic Action against Bacterial Cells: Inhibition of Cell Wall Synthesis (most common mechanism) Inhibition of Protein Synthesis (Translation) (second largest class) Alteration of Cell Membranes; Inhibition of Nucleic Acid Synthesis Vancomycin ---> Disrupts peptidoglycan cross-linkage Resistance ---> Vancomycin (oral) is a glycopeptide, antibiotics that is FDA approved for the treatment of C. difficile-associated diarrhea, enterocolitis caused by Staphylococcus aureus (including methicillin-resistant strains). Common adverse reactions include nausea, vomiting, abdominal pain, diarrhea, and hypokalemia

Vancomycin. Mechanism of action Inhibits bacterial cell wall synthesis ; Spectrum of action Gram positive organisms ; Including Listeria, Rhodococcus, Peptostreptococcus ; Bacteriostatic against enterococcus ; Mechanism of resistance ; Enterococcus Van A E ; Peptidoglycan precursor has decreased affinity for vancomycin D-ala-D-ala replaced by D. Mechanism of action of Vancomycin : Vancomycin Prevents Incorporation Of N-acetylmuramic Acid (NAM)- And N-acetylglucosamine (NAG)-peptide Subunits From Being Incorporated Into The Peptidoglycan Matrix; Which Forms The Major Structural Component Of Gram-positive Cell Walls. The Large Hydrophilic Molecule Is Able To Form Hydrogen Bond. The mechanism by which vancomycin exerts its action is by preventing the synthesis of peptidoglycan precursors of the bacterial cell wall by blocking the transglycosylation step and subsequently affecting the transpeptidation step also [3, 5]. Both the transglycosylation and transpeptidation steps are essential for bacterial cell wall cross. SUMMARY As the leading cause of hospital-acquired diarrhea, Clostridium difficile colonizes the large bowel of patients undergoing antibiotic therapy and produces two toxins, which cause notable disease pathologies. These two toxins, TcdA and TcdB, are encoded on a pathogenicity locus along with negative and positive regulators of their expression VANCOMYCIN Lakshmi Narayana M

Vancomycin binds directly to alanine residues and in. Penicillin Mechanism Of Action. 06-01-2016. Protein Synthesis Inhibitors. 06-01-2016. Vancomycin. 06-01-2016. About Us. Pharmacology animation book is a website that provides free animation videos for almost all important pharmacological subjects. It is arranged in units of major. About vancomycin; Vancomycin review; Learn vancomycin faster with picmonic (nclex nursing school) Vancomycin-resistant enterococci (vre) in healthcare environ... Vancomycin/ bacterial targets, mechanism of action, adverse Vancomycin: what you need to know; About Vancomycin Vancomycin-induced renal toxicity was reported in 10-20 % and 30-40 % of patients following conventional and high doses of vancomycin therapy, respectively .The most probable mechanism for its. Vancomycin is in a class of medications called glycopeptide antibiotics. It works by killling bacteria in the intestines. Vancomycin will not kill bacteria or treat infections in any other part of the body when taken by mouth. Antibiotics will not work for colds, flu, or other viral infections Vancomycin-Resistant Enterococcus faecium Infections - Pipeline Review, H2 2015 Summary Global Markets Direct s, Vancomycin-Resistant Enterococcus Faecium Infections - Pipeline Review, H2 2015.

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Older animation describing the mechanism of action of vancomycin by inhibition of peptidoglycan layer biosynthesi The mechanism of action for vancomycin hinges on the ability of the glycopeptide to complex with D-ala moieties during peptidoglycan synthesis and block formation of cell wall structural components. In vitro studies demonstrate that vancomycin exhibits primarily time dependent bactericidal activities and that higher drug concentrations do not. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except. Teixobactin had excellent bactericidal activity against aureus, MRSA (Methicillin Resistant Staphylococcus aurues and Vancomycin Intermediate Staphylococcus aureus (VISA) Mechanism of Action: Teixobactin is an unusual depsipeptide which contains enduracididine, methylphenylalanine, and four D-amino acids

Vancomycin has been used to study transcriptional induction of the penicillin-binding protein 2 gene in Staphylococcus aureus, the correlation of vancomycin and daptomycin susceptibility in Staphylococcus aureus, and the evaluation of telavancin activity in Staphylococcus aureus. Biochem/physiol Actions This indicates that there is a distinction in antimicrobial mechanism of action: teicoplanin inhibits more transpeptidation while vancomycin is more inclined to inhibit transglycosylation . In addition, vancomycin and teicoplanin belong to different side-chain linkage patterns and carbohydrate groups [40] QUESTION 2 Match each of the following drugs with their mechanism of action v Vancomycin A. binds to the C55 carrier lipid to prevent NAM- F. clavulonic acid pentapeptide from crossing the cell membrane v Cephalosporin B. prevents the formation of D-Ala-D-Ala v Penicillin G C. blocks transglycosidation D-Cycloserine D. inhibits dihydrofolate reductase blocking the biosynthesis of.

Therapeutics in dentistry (antibiotics)Schaefer, Joseph, RAntibioticsAntimicrobial agents and mechanisms of action 2Antibiotic classes
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